Steingart et al. have assessed the diagnostic accuracy of Xpert for pulmonary TB and for rifampicin resistance in this Cochrane Review. The review found that Xpert achieved a pooled sensitivity of 88% and specificity of 98% when used as an initial test replacing smear microscopy, and as an add-on test following a negative smear result, Xpert yielded a pooled sensitivity of 67% and specificity of 98%. The authors concluded that Xpert used as an initial diagnostic test for TB detection and rifampicin resistence is sensitive and specific.
For more information on this Cochrane Review or to read the article, click here.