This video seminar describes research to develop a low-cost, field-based test to detect several slow-clearing ACT drug compounds from unprocessed fingerstick blood samples
The European Mobile Laboratory, EMLab, was the first EBOV diagnostics unit deployed to the outbreak epicentre by WHO in March 2014.
Laboratory systems and diagnostic technologies are a critical pillar in the fight against malaria. The World Health Organization (WHO) recommends diagnostic testing for all people with suspected malaria before treatment is administered.
Call for Papers: Special issue on strengthening tuberculosis diagnostic networks in Africa - African Journal of Laboratory Medicine
From our colleagues at the African Society for Laboratory Medicine (ASLM) - The Role of Public Health Institutes in Achieving Public Health Goals
East African Leaders Join Together to Develop Country-Specific Plans for Point-of-Care Testing.
Pioneering New Diagnostics: Addressing Challenges and Implications for Point-of-Care Testing in African Settingsby Laurel Oldach
An article highlighting the importance of diagnostics for NTDs, and providing a good overview on their development from a policy perspective.
Prioritizing Congenital Syphilis Control in South China: A Decision Analytic Model to Inform Policy Implementationby Nicholas X. Tan, Chara Rydzak, Li-Gang Yang, Peter Vickerman, Bin Yang, Rosanna W. Peeling, Sarah Hawkes, Xiang-Sheng Chen, Joseph D. Tucker
Postmarket Surveillance of Medical Devices: A Comparison of Strategies in the US, EU, Japan, and Chinaby Daniel B. Kramer, Yongtian T. Tan, Chiaki Sato, Aaron S. Kesselheim
Use of Expert Panels to Define the Reference Standard in Diagnostic Research: A Systematic Review of Published Methods and Reportingby Loes c. M. Vertens, Berna D. L. Broekhuizen, Christiana A. Naaktgeboren, Frans H. Rutten, Amy W. Hoes, Yvonne van Mourik, Karel G. M. Moons, Johannes B. Reitsma
How to Improve the early Diagnosis of Trypanosoma cruzi Infection: Relationship between Validated Conventional Diagnosis and Quantitative DNA Amplification in Congenitally Infected Childrenby Jacqueline Bua, Bibiana J. Volta, Alina E. Perrone, Karenina Scollo, Elsa B. Velazquez, Andres M. Ruiz, Ana M. De Rissio, Rita L. Cardoni
Identification of Seroreactive Proteins of Leptospira interrogans Serovar Copenhageni Using a High-Density Protein Microarray Approachby Carolina Lessa-Aquino, Camila Borges Rodrigues, Jozelyn Pablo, Rie Sasaki, Algis Jasinskas, Li Liang, Elsio A. Wunder Jr, Guilherme S. Ribeiro, Adam Vigil, Ricardo Galler, Douglas Molina, Xiaowu Liang, Mitermayer G. Reis, Albert I. Ko, Marco Alberto Medeiros, Philip L. Felgner
Diagnostic Accuracy of Loopamp Trypanosoma brucei Detection Kit for Diagnosis of Human African Trypanosomiasis in Clinical Samplesby Patrick Mitashi, Epco Hasker, Dieudonne Mumba Ngoyi, Pati Patient Pyana, Veerle Lejon, Wim Van der Veken, Pascal Lutumba, Philippe Buscher, Marleen Boelaert, Stijn Deborggraeve
Analytical and Clinical Performance of the CDC Real Time RT-PCR Assay for Detection and Typing of Dengue Virusby Gilberto A Santiago, Edgardo Vergne, Yashira Quiles, Joan Cosme, Jesus Vazquez, Juan F. Medina, Freddy Medina, Candimar Colon, Harold Margolis, Jorge L. Munoz-Jordan
Evaluation of a Typhoid/Paratyphoid Diagnostic Assay (TPTest) Detecting Anti-Salmonella IgA in Secretions of Peripheral Blood in Lymphocytes in Patients in Dhaka, Bangladeshby Farhana Khanam, Alaullah Sheikh, Abu Sayeed, Saraur Bhuiyan, Feroza Kaneez Choudhury, Umme Salma, Shahnaz Pervin, Tania Sultana, Dilruba Ahmed, Doli Goswami, Lokman Hossain, KZ Mamun, Richell C Charles, W. Abdullah Brooks, Stephen B. Calderwood, Alejandro Cravioto, Edward T Ryan, Firdausi Qadri
Randomised Clinical Trial Investigating the Specificity of Novel Skin Test (C-Tb) for Diagnosis of M. tuberculosis Infectionby Henrik Aggerbeck, Rafaela Giemza, Paulatsya Joshi, Pernille N. Tingskov, Soren T. Hoff, Julia Boyle, Peter Andersen, David J. M. Lewis
Diagnosis of Visceral Leishmaniasis in Bihar India: Comparison of the rK39 Rapid Diagnostic Test on Whole Blood Versus Serumby Greg Matlashewski, Vidya Nand Ravi Das, Krishna Pandey, Dharmendra Singh, Sushmita Das, Ayan Kumar Ghosh, Ravindra Nath Pandey, Pradeep Das
Rapid Syphilis Testing Uptake for Female Sex Workers at Sex Venues in Southern China: Implication for Expanding Syphilis Screeningby Xiang-Sheng Chen, Yeu-Ping Yin, Crystal Shen, Guo-Gu Liu, Zheng-Jun Zhu, Wan-Hui Wei, Hong-Chun Wang, Shui-Jie Huang, Jing Li, Joseph D Tucker, David Mabey, Rosanna Peeling
Development and Validation of a Novel Diagnostic Test for Human Brucellosis Using a Glyco-engineered Antigen Coupled to Magnetic Beadsby Andrés E. Ciocchini, Diego A. Rey Serantes, Luciano J. Melli, Jeremy A. Iwashkiw, Bettina Deodata, Jorge Wallach, Mario F. FEldman, Juan E. Ugalde, Diego J. Comerci
Leishmaniasis Direct Agglutination Test: Using Pictorials as Training Materials to REduce Inter-Reader Variability and Improve Accuracyby Emily R Adams, Diane Jacquet, Gerard Schoone, Kamlesh Gidwani, Marleern Boelaert, Jane Cunningham
Field Evaluation and Impact on Clinical Management of a Rapid Diagnostic Kit That Detects Dengue NS1, IgM and IgGby Anne-Claire Andries, Veasna Duong, Chantha Ngan, Sivuth Ong, Rekol Huy, Kim Kim Sroin, Vantha Te, Bunthin Y, Patrich Lorn Try, Philippe Buchy
Uptake of Home-Based Voluntary HIV Testing in Sub-Saharan Africa: A Systematic Review and Met-Analysisby Kalpana Sabapathy, Rafael Van den Bergh, Sarah Fidler, Richard Hayes, Nathan Ford
Point of Care Testing for Infectious Diseases: Diversity, Complexity and Barriers in Low- and Middle Income Countriesby Nitika Pant Pai, MD MPH PhD, Caroline Vadnais, Claudia Denkinger, Nora Engel, Madhu Pai
First International External Quality Assessment of Molecular Detection of Crimean-Congo Hemorrhagic Fever Virusby Camille Escadafal, Stephan Olschlager, Tatjana Avsic Zupanc, Anna Papa, Jessica Vanhomwegen, Roman Wolfel, Ali Mirazimi, Annette Teichmann, Oliver Donoso Mantke, Matthias Niedriq
The Human African Trypanosomiasis Specimen Biobank: A Necessary Tool to Support Research of New Diagnosticsby Jose R Franco, Pere P Simarro, Abdoulaye Diarra, Jose A. Ruiz-Postigo, Jean G. Jannin
A Research Agenda for Helminth Diseases of Humans: Diagnostics for Control and Elimination Programmesby James S. McCarthy, Sara Lustigman, Guo-Jing Yang, Rashida M. Barakat, Héctor H. García, Banchob Sripa, Arve Lee Willingham, Roger K. Prichard, María-Gloria Basáñez
Diagnostic Accuracy of Molecular Amplification Tests for Human African Trypanosomiasis—Systematic Reviewby Claire M. Mugasa, Emily R. Adams, Kimberly R. Boer, Heleen C. Dyserinck, Philippe Büscher
Free treatment, rapid malaria diagnostic tests and malaria village workers can hasten progress toward achieving the malaria related millennium development goalsby Katie Tayler-Smith, Alice Kociejowski ,1,3 ,3 Mit, Nadine de Lamotte, Seco Gerard, Frederique Ponsar, Mit Philips, Rony Zachariah
Early infant diagnosis of HIV infection in Zambia through mobile phone texting of blood test resultsby Phil Seidenberg, Stephen Nicholson , Merrick Schaefer, Katherine Semrau, Maximillian Bweupe, Noel Masese, Rachael Bonawitz, Lastone Chitembo, Caitlin Goggin, Donald M Thea
Optimal monitoring strategies for guiding when to switch first-line antiretroviral therapy regimens for treatment failure in adults and adolescentsby LW Chang, J Harris, E Humphreys
Multi-site evaluation of a point-of-care instrument for CD4+ T cell enumeration using venous and finger prick blood: the PIMA CD4by Papa Alassana Diaw, Geraldine Daneau, Abdoul Coly, Birahim Pierre Ndiaye, Dribril Wade, Makhtar Camara, Souleymane Mboup, Luc Kestens, Tandakha Ndiaye Dieye
CD4+ cell count testing more effective than HIV disease clinical staging in identifying pregnant and postpartum women eligible for antiretroviral therapy in resource-limited settingsby Rosalind Carter, Kate Dugan, Wafaa El-Sadr, Landon Myer, Juliana Otieno, Nattaya Pungpapong, Patricia Toro, Elaine Abrams
This review, written by Ruth McNerney and Peter Daley, provides an overview of the state of research into point-of-care diagnostics for active tuberculosis and highlights the barriers to the development of these tests.