This is a great video of a talk given at the Oxford Martin School by Professor Kevin Marsh.
Field trials of interventions against disease in low and middle income countries (LMICs) may be complex and expensive undertakings. This 3rd edition of the Field Trials Toolbox has been compiled by over 30 contributors with extensive direct experience in the design, conduct, and analysis of field trials in LMICs, and it attempts to document their accumulated experience for the guidance of those who might undertake field trials of health interventions. It can be read in its entirety as an introduction to the field and/or can serve as a reference volume during each of the different stages of planning, conducting, and analysing a field trial.
AuthorAid is a great online tool whose aim is to support developing country researchers in publishing their work.
A programme set up by WHO together with major publishers to provide free or very low cost online access to the major journals to local, not-for-profit institutions in developing countries.
This report, provided by Uniting to Combat NTDs, presents the achievements in 2013 on the control and eradication of Neglected Tropical Diseases and includes data on disease burden, epidemiology, etc... of the individual diseases.
Social science guidance from the ACT Consortium available for wider research community, including training materials, SOPs, template protoclos and other tools.
ESSENCE on Health Research have created a good practice document on research costing. It includes a review of the funding practices related to the definition and funding of direct and indirect costs.
This guide, developed by the WHO and released in December 2013, aims to facilitate implementation research in LMICs.
Towards an Understanding of Disengagement from HIV Treatment and Care in Sub-Saharan Africa: A Qualitative Studyby Norma C. Ware, Monique A. Wyatt, Elvin H. Geng, Sylvia F. Kaaya, Oche O. Agbaji, Winnie R. Muyindike, Guerino Chalamilla, Patricia A. Agaba
Prioritizing Congenital Syphilis Control in South China: A Decision Analytic Model to Inform Policy Implementationby Nicholas X. Tan, Chara Rydzak, Li-Gang Yang, Peter Vickerman, Bin Yang, Rosanna W. Peeling, Sarah Hawkes, Xiang-Sheng Chen, Joseph D. Tucker
Postmarket Surveillance of Medical Devices: A Comparison of Strategies in the US, EU, Japan, and Chinaby Daniel B. Kramer, Yongtian T. Tan, Chiaki Sato, Aaron S. Kesselheim
Use of Expert Panels to Define the Reference Standard in Diagnostic Research: A Systematic Review of Published Methods and Reportingby Loes c. M. Vertens, Berna D. L. Broekhuizen, Christiana A. Naaktgeboren, Frans H. Rutten, Amy W. Hoes, Yvonne van Mourik, Karel G. M. Moons, Johannes B. Reitsma
Elimination of Schistosomiasis Transmission in Zanzibar: Baseline Findings before the Onset of a Randomized Intervention Trialby Stefanie Knopp, Bobbie Person, Shaali M. Ame, Khalfan A. Mohammed, Said M. Ali, I. Simba Khamis, Muriel Rabone, Fiona Allan, Anouk Gouvras, Lynsey Blair, Alain Fenwick, Jurg Utzinger, David Rollinson
How to Improve the early Diagnosis of Trypanosoma cruzi Infection: Relationship between Validated Conventional Diagnosis and Quantitative DNA Amplification in Congenitally Infected Childrenby Jacqueline Bua, Bibiana J. Volta, Alina E. Perrone, Karenina Scollo, Elsa B. Velazquez, Andres M. Ruiz, Ana M. De Rissio, Rita L. Cardoni
Identification of Seroreactive Proteins of Leptospira interrogans Serovar Copenhageni Using a High-Density Protein Microarray Approachby Carolina Lessa-Aquino, Camila Borges Rodrigues, Jozelyn Pablo, Rie Sasaki, Algis Jasinskas, Li Liang, Elsio A. Wunder Jr, Guilherme S. Ribeiro, Adam Vigil, Ricardo Galler, Douglas Molina, Xiaowu Liang, Mitermayer G. Reis, Albert I. Ko, Marco Alberto Medeiros, Philip L. Felgner
Diagnostic Accuracy of Loopamp Trypanosoma brucei Detection Kit for Diagnosis of Human African Trypanosomiasis in Clinical Samplesby Patrick Mitashi, Epco Hasker, Dieudonne Mumba Ngoyi, Pati Patient Pyana, Veerle Lejon, Wim Van der Veken, Pascal Lutumba, Philippe Buscher, Marleen Boelaert, Stijn Deborggraeve
Rapid Syphilis Testing Uptake for Female Sex Workers at Sex Venues in Southern China: Implication for Expanding Syphilis Screeningby Xiang-Sheng Chen, Yeu-Ping Yin, Crystal Shen, Guo-Gu Liu, Zheng-Jun Zhu, Wan-Hui Wei, Hong-Chun Wang, Shui-Jie Huang, Jing Li, Joseph D Tucker, David Mabey, Rosanna Peeling
Development and Validation of a Novel Diagnostic Test for Human Brucellosis Using a Glyco-engineered Antigen Coupled to Magnetic Beadsby Andrés E. Ciocchini, Diego A. Rey Serantes, Luciano J. Melli, Jeremy A. Iwashkiw, Bettina Deodata, Jorge Wallach, Mario F. FEldman, Juan E. Ugalde, Diego J. Comerci
In determining the feasibility of establishing a biorepository at your facility, there are several key factors to consider. But first, there are a few that must be in place before commencing. They are:
- The commitment of your institutional
- The trust of the community within which you work
- Informed consents that allow specimens to be used for multiple research studies
- Vision/commitment for the distribution and sharing of biospecimens and data with the wider scientific community
Leishmaniasis Direct Agglutination Test: Using Pictorials as Training Materials to REduce Inter-Reader Variability and Improve Accuracyby Emily R Adams, Diane Jacquet, Gerard Schoone, Kamlesh Gidwani, Marleern Boelaert, Jane Cunningham
Field Evaluation and Impact on Clinical Management of a Rapid Diagnostic Kit That Detects Dengue NS1, IgM and IgGby Anne-Claire Andries, Veasna Duong, Chantha Ngan, Sivuth Ong, Rekol Huy, Kim Kim Sroin, Vantha Te, Bunthin Y, Patrich Lorn Try, Philippe Buchy
Uptake of Home-Based Voluntary HIV Testing in Sub-Saharan Africa: A Systematic Review and Met-Analysisby Kalpana Sabapathy, Rafael Van den Bergh, Sarah Fidler, Richard Hayes, Nathan Ford
Point of Care Testing for Infectious Diseases: Diversity, Complexity and Barriers in Low- and Middle Income Countriesby Nitika Pant Pai, MD MPH PhD, Caroline Vadnais, Claudia Denkinger, Nora Engel, Madhu Pai
Identification of Mimotopes with Diagnostic Potential for Trypanosoma brucei gambiense Varient Surfance Glycoproteins Using Human Antibody Fractionsby Liesbeth Van Nieuwenhove, Philippe Buscher, Fatima Balharbi, Michael Humbert, Tessa Dieltjens, Yves Guisez, Veerle Lejon
First International External Quality Assessment of Molecular Detection of Crimean-Congo Hemorrhagic Fever Virusby Camille Escadafal, Stephan Olschlager, Tatjana Avsic Zupanc, Anna Papa, Jessica Vanhomwegen, Roman Wolfel, Ali Mirazimi, Annette Teichmann, Oliver Donoso Mantke, Matthias Niedriq
The Human African Trypanosomiasis Specimen Biobank: A Necessary Tool to Support Research of New Diagnosticsby Jose R Franco, Pere P Simarro, Abdoulaye Diarra, Jose A. Ruiz-Postigo, Jean G. Jannin
Diagnostic Accuracy of Molecular Amplification Tests for Human African Trypanosomiasis—Systematic Reviewby Claire M. Mugasa, Emily R. Adams, Kimberly R. Boer, Heleen C. Dyserinck, Philippe Büscher
“Piggy-Backing” on Diagnostic Platforms Brings Hope to Neglected Diseases: The Case of Sleeping Sicknessby Joseph M Ndung'u , Sylvain Bieler, Giorgio Roscigno
Free treatment, rapid malaria diagnostic tests and malaria village workers can hasten progress toward achieving the malaria related millennium development goalsby Katie Tayler-Smith, Alice Kociejowski ,1,3 ,3 Mit, Nadine de Lamotte, Seco Gerard, Frederique Ponsar, Mit Philips, Rony Zachariah
CD4+ cell count testing more effective than HIV disease clinical staging in identifying pregnant and postpartum women eligible for antiretroviral therapy in resource-limited settingsby Rosalind Carter, Kate Dugan, Wafaa El-Sadr, Landon Myer, Juliana Otieno, Nattaya Pungpapong, Patricia Toro, Elaine Abrams
Effect of point-of-care CD4 cell count tests on retention of patients and rates of antiretroviral therapy initiation in primary health clinics: an observational cohort studyby Ilesh Jani, Nádia Sitoe, Eunice Alfai, Patrina Chongo, Jorge Quevedo, Beatriz Rocha, Jonathan Lehe
Head-to-head comparison of accuracy of a rapid point-of care HIV test with oral versus whole-blood specimensby Nitika Pant Pai, MD MPH PhD, B. Balram, S. Shivkumar, J.L Martinex-Cajas, C. Claessens, G. Lambert, Rosanna Peeling, L. Joseph
This review, written by Ruth McNerney and Peter Daley, provides an overview of the state of research into point-of-care diagnostics for active tuberculosis and highlights the barriers to the development of these tests.