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"Which New Diagnostics for Tuberculosis, and When?" advocates for a need for further guidance for tuberculosis programs beyond the World Health Organization (WHO) endorsement based on the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) process. While the GRADE endorsement is based on evidence on test accuracy, it does not inform tubeculosis programs about which new diagnostics to scale up and how to best position them in diagnostic algorithm. The article suggests that the WHO endorsement should be revised to consist of both a technical recommendation and programmatic recommendation.