Invitation to complete quick survey to improve Kaplan-Meier plots (KMunicate) ProblemThe standard way to present time-to-event data, such as survival, is with Kaplan-Meier plots. These are formatted by journals and reported in a number of ways, but we find they commonly lack some key information. The key problems are:
- Expressing how many people are contributing data at any point in the graph, including the pattern of censoring
- Expressing that the uncertainty of the estimate increases over time
This is a great video of a talk given at the Oxford Martin School by Professor Kevin Marsh.
Around half of the clinical trials done on medicines we use today are not published; a tragic truth that needs to be changed.
This video seminar describes research to develop a low-cost, field-based test to detect several slow-clearing ACT drug compounds from unprocessed fingerstick blood samples
The team interview panel members talking about the Novartis Access Initiative's work on NCDs.
This review describes the landscape of schistosomiasis clinical research. The volume of data and the methodological and reporting heterogeneity identified all indicate that there is scope for an individual participant-level database, to allow for standardised analyses.
The European Mobile Laboratory, EMLab, was the first EBOV diagnostics unit deployed to the outbreak epicentre by WHO in March 2014.
Laboratory systems and diagnostic technologies are a critical pillar in the fight against malaria. The World Health Organization (WHO) recommends diagnostic testing for all people with suspected malaria before treatment is administered.
U.S. efforts to combat the Zika virus in the US and abroad
Travel Medicine and Infectious Diseases have evolved rapidly in recent decades as outbreaks such as SARS, Avian Influenza, Ebola, MERS, Chikungunya, and Zika virus have demonstrated how quickly infections can cross international borders.
The Zika virus is another wild card dealt to us by nature. It was first discovered in 1947.
Video seminar by Chelsea McMullen, Operational Support Officer, International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), presented at the University of Oxford, 21st October 2015
Call for Papers: Special issue on strengthening tuberculosis diagnostic networks in Africa - African Journal of Laboratory Medicine
Deployed in April 2015, we have established proof-of-principle for real-time genomic surveillance by generating over 40 genome sequences in as little as 48 hours from obtaining a patient sample and feeding the information back to the Ebola central coordination team.
From our colleagues at the African Society for Laboratory Medicine (ASLM) - The Role of Public Health Institutes in Achieving Public Health Goals
Damalie Nakanjako (MBChB, MMED, PhD) is an internist whose work focuses on optimizing HIV treatment outcomes and reducing HIV-associated morbidity and mortality in sub-Saharan Africa.
East African Leaders Join Together to Develop Country-Specific Plans for Point-of-Care Testing.
Two great articles from the African Society for Laboratory Medicine looking at the increasing risk posed by antimicrobial resistance.
New articles from the African Society for Laboratory Medicine (ASLM).
This study evaluates whether the use of rapid diagnostic tests by community medicine distributors – with the aim to improve diagnosis and treatment of malaria in the community – is feasible, well accepted and cost-effective. This cluster randomized trial compares two approaches.
Healthcare associated infections (HAI) are of important concern in patient care. This talk discusses Visual Analytics techniques which have been developed to help detect, monitor, analyse and understand trends, clusters and outbreaks of HAI.
The SWAT and SWAR programme is identifying issues about the methods of trials and systematic reviews about which there is sufficient uncertainty to justify research to support well-informed decision making about future designs and choices.
Schistosomiasis, is a chronic, debilitating disease. Uganda began a National Control Programme in 2003 with annual MDA of praziquantel. MDA on this scale provides strong selective pressures on the parasite population with an associated risk of drug resistance developing.
In this video, Professor Theonest Mutabingwa discusses the two key challenges that face developing countries to progress their malaria research.
In this video of a seminar delivered at the University of Oxford in June 2014, Professor Nicholas White talks about the challenge of antimalarial resistance.
Anders Björkman is Professor of Infectious Disease at the Karolinska Institute. In this video, Anders talks about how the efficacy of antimalarials is a major obstacle in the path towards full malaria elimination.
Are you a research scientist working in Global Health? Or an institution looking for partners to run a clinical trial? Site Finder is for you.
In this seminar from January 2014, Dr Jane Crawley talks about clinical standardisation in PERCH (Pneumonia Etiology Research for Child Health), a large case-control study of the causes of and risk factors for severe pneumonia.
Dr Nat Segaren - Medical Director of the Caris Foundation, presents on 'The Haiti National Early Infant Diagnosis of HIV Program'
In this seminar Professor Kevin Marsh describes how knowledge of immunity to malaria in humans has developed over the past thirty years and what impact this has for future research.
Pioneering New Diagnostics: Addressing Challenges and Implications for Point-of-Care Testing in African Settingsby Laurel Oldach
Sam Sia is an Associate Professor at Columbia University and was voted one of MITs top innovators under 35 in 2010 for his work on designing inexpensive microfluidic chips for diagnostics. Sam's most recent work has focused on developing a diagnostic device that can be connected as a dongle to a smartphone and used to diagnose HIV and syphilis.
Seeding Labs is an initiative connecting labs in developing countries with labs that have equipment, consumables, manuals or glassware to donate, and provides the infrastructure.
Professor Peter Piot, LSHTM, talks about Ebola and implications for Africa and understanding future epidemics at the Martin School, University of Oxford, 16th October 2014.
Ebola PPE guidelines - urgent need to revise WHO and CDC guidelines. This video shows an excerpt from keynote address 'The fuss about face masks', Professor Raina MacIntyre from the School of Public Health and Community Medicine, UNSW Australia.
The Ebola virus epidemic may well spread out of Africa. Dr Greg Martin takes a look at some of the variables that contribute to this risk and discusses some steps that should be taken.
On the 8th of July 2014 The Global Health Network launched the Global Health Research Process Map, the first digital toolkit designed to enable researchers anywhere in the world to conduct rigorous global health research.
Seven principles for strengthening research capacity in low- and middle-income countries: simple ideas in a complex worldby ESSENCE on Health Research Initiative
This good practice document of the ESSENCE on Health Research initiative is designed to provide broad guidance on how best to strengthen research capacity with the maximum possible benefit.
AuthorAid is a great online tool whose aim is to support developing country researchers in publishing their work.
A programme set up by WHO together with major publishers to provide free or very low cost online access to the major journals to local, not-for-profit institutions in developing countries.
Two recent articles in the Lancet Global Health give an interesting overview on diagnosis and treatment of Yaws, an endemic treponematose closely related to syphilis.
Methods for Specifying the Target Difference in a Randomised Controlled Trial: The Difference ELicitation in TriAls (DELTA) Systematic Reviewby Jai K Das
Randomised controlled trials (RCTs) are widely accepted as the preferred study design for evaluating healthcare interventions. When the sample size is determined, a (target) difference is typically specified that the RCT is designed to detect. This provides reassurance that the study will be informative, i.e., should such a difference exist, it is likely to be detected with the required statistical precision. The aim of this review was to identify potential methods for specifying the target difference in an RCT sample size calculation.
This report, provided by Uniting to Combat NTDs, presents the achievements in 2013 on the control and eradication of Neglected Tropical Diseases and includes data on disease burden, epidemiology, etc... of the individual diseases.
An article highlighting the importance of diagnostics for NTDs, and providing a good overview on their development from a policy perspective.
ESSENCE on Health Research have created a good practice document on research costing. It includes a review of the funding practices related to the definition and funding of direct and indirect costs.
This guide, developed by the WHO and released in December 2013, aims to facilitate implementation research in LMICs.
Prioritizing Congenital Syphilis Control in South China: A Decision Analytic Model to Inform Policy Implementationby Nicholas X. Tan, Chara Rydzak, Li-Gang Yang, Peter Vickerman, Bin Yang, Rosanna W. Peeling, Sarah Hawkes, Xiang-Sheng Chen, Joseph D. Tucker
Postmarket Surveillance of Medical Devices: A Comparison of Strategies in the US, EU, Japan, and Chinaby Daniel B. Kramer, Yongtian T. Tan, Chiaki Sato, Aaron S. Kesselheim
Elimination of Schistosomiasis Transmission in Zanzibar: Baseline Findings before the Onset of a Randomized Intervention Trialby Stefanie Knopp, Bobbie Person, Shaali M. Ame, Khalfan A. Mohammed, Said M. Ali, I. Simba Khamis, Muriel Rabone, Fiona Allan, Anouk Gouvras, Lynsey Blair, Alain Fenwick, Jurg Utzinger, David Rollinson
How to Improve the early Diagnosis of Trypanosoma cruzi Infection: Relationship between Validated Conventional Diagnosis and Quantitative DNA Amplification in Congenitally Infected Childrenby Jacqueline Bua, Bibiana J. Volta, Alina E. Perrone, Karenina Scollo, Elsa B. Velazquez, Andres M. Ruiz, Ana M. De Rissio, Rita L. Cardoni
Identification of Seroreactive Proteins of Leptospira interrogans Serovar Copenhageni Using a High-Density Protein Microarray Approachby Carolina Lessa-Aquino, Camila Borges Rodrigues, Jozelyn Pablo, Rie Sasaki, Algis Jasinskas, Li Liang, Elsio A. Wunder Jr, Guilherme S. Ribeiro, Adam Vigil, Ricardo Galler, Douglas Molina, Xiaowu Liang, Mitermayer G. Reis, Albert I. Ko, Marco Alberto Medeiros, Philip L. Felgner
Diagnostic Accuracy of Loopamp Trypanosoma brucei Detection Kit for Diagnosis of Human African Trypanosomiasis in Clinical Samplesby Patrick Mitashi, Epco Hasker, Dieudonne Mumba Ngoyi, Pati Patient Pyana, Veerle Lejon, Wim Van der Veken, Pascal Lutumba, Philippe Buscher, Marleen Boelaert, Stijn Deborggraeve
Analytical and Clinical Performance of the CDC Real Time RT-PCR Assay for Detection and Typing of Dengue Virusby Gilberto A Santiago, Edgardo Vergne, Yashira Quiles, Joan Cosme, Jesus Vazquez, Juan F. Medina, Freddy Medina, Candimar Colon, Harold Margolis, Jorge L. Munoz-Jordan
Evaluation of a Typhoid/Paratyphoid Diagnostic Assay (TPTest) Detecting Anti-Salmonella IgA in Secretions of Peripheral Blood in Lymphocytes in Patients in Dhaka, Bangladeshby Farhana Khanam, Alaullah Sheikh, Abu Sayeed, Saraur Bhuiyan, Feroza Kaneez Choudhury, Umme Salma, Shahnaz Pervin, Tania Sultana, Dilruba Ahmed, Doli Goswami, Lokman Hossain, KZ Mamun, Richell C Charles, W. Abdullah Brooks, Stephen B. Calderwood, Alejandro Cravioto, Edward T Ryan, Firdausi Qadri
Randomised Clinical Trial Investigating the Specificity of Novel Skin Test (C-Tb) for Diagnosis of M. tuberculosis Infectionby Henrik Aggerbeck, Rafaela Giemza, Paulatsya Joshi, Pernille N. Tingskov, Soren T. Hoff, Julia Boyle, Peter Andersen, David J. M. Lewis
Diagnosis of Visceral Leishmaniasis in Bihar India: Comparison of the rK39 Rapid Diagnostic Test on Whole Blood Versus Serumby Greg Matlashewski, Vidya Nand Ravi Das, Krishna Pandey, Dharmendra Singh, Sushmita Das, Ayan Kumar Ghosh, Ravindra Nath Pandey, Pradeep Das
Development and Validation of a Novel Diagnostic Test for Human Brucellosis Using a Glyco-engineered Antigen Coupled to Magnetic Beadsby Andrés E. Ciocchini, Diego A. Rey Serantes, Luciano J. Melli, Jeremy A. Iwashkiw, Bettina Deodata, Jorge Wallach, Mario F. FEldman, Juan E. Ugalde, Diego J. Comerci
These guidelines help address the urgent need to develop tests that can work in children, ideally using non-sputum based samples. It is vital that these reference standards are endorsed and implemented by the major donors, researchers and diagnostic developers.
Uptake of Home-Based Voluntary HIV Testing in Sub-Saharan Africa: A Systematic Review and Met-Analysisby Kalpana Sabapathy, Rafael Van den Bergh, Sarah Fidler, Richard Hayes, Nathan Ford
Repository on maternal child health: Health portal to improve access to information on maternal child health in Indiaby Jai K Das
This article describes a health portal developed in India aimed at providing one-stop access to efficiently search, organize and share maternal child health information relevant from public health perspective in the country.
Point of Care Testing for Infectious Diseases: Diversity, Complexity and Barriers in Low- and Middle Income Countriesby Nitika Pant Pai, MD MPH PhD, Caroline Vadnais, Claudia Denkinger, Nora Engel, Madhu Pai
This article is an introduction to cluster randomised trials.
Identification of Mimotopes with Diagnostic Potential for Trypanosoma brucei gambiense Varient Surfance Glycoproteins Using Human Antibody Fractionsby Liesbeth Van Nieuwenhove, Philippe Buscher, Fatima Balharbi, Michael Humbert, Tessa Dieltjens, Yves Guisez, Veerle Lejon
First International External Quality Assessment of Molecular Detection of Crimean-Congo Hemorrhagic Fever Virusby Camille Escadafal, Stephan Olschlager, Tatjana Avsic Zupanc, Anna Papa, Jessica Vanhomwegen, Roman Wolfel, Ali Mirazimi, Annette Teichmann, Oliver Donoso Mantke, Matthias Niedriq
The Human African Trypanosomiasis Specimen Biobank: A Necessary Tool to Support Research of New Diagnosticsby Jose R Franco, Pere P Simarro, Abdoulaye Diarra, Jose A. Ruiz-Postigo, Jean G. Jannin
A Research Agenda for Helminth Diseases of Humans: Diagnostics for Control and Elimination Programmesby James S. McCarthy, Sara Lustigman, Guo-Jing Yang, Rashida M. Barakat, Héctor H. García, Banchob Sripa, Arve Lee Willingham, Roger K. Prichard, María-Gloria Basáñez
Diagnostic Accuracy of Molecular Amplification Tests for Human African Trypanosomiasis—Systematic Reviewby Claire M. Mugasa, Emily R. Adams, Kimberly R. Boer, Heleen C. Dyserinck, Philippe Büscher
“Piggy-Backing” on Diagnostic Platforms Brings Hope to Neglected Diseases: The Case of Sleeping Sicknessby Joseph M Ndung'u, Sylvain Bieler, Giorgio Roscigno
Free treatment, rapid malaria diagnostic tests and malaria village workers can hasten progress toward achieving the malaria related millennium development goalsby Katie Tayler-Smith, Alice Kociejowski ,1,3 ,3 Mit, Nadine de Lamotte, Seco Gerard, Frederique Ponsar, Mit Philips, Rony Zachariah
Early infant diagnosis of HIV infection in Zambia through mobile phone texting of blood test resultsby Phil Seidenberg, Stephen Nicholson, Merrick Schaefer, Katherine Semrau, Maximillian Bweupe, Noel Masese, Rachael Bonawitz, Lastone Chitembo, Caitlin Goggin, Donald M Thea
Optimal monitoring strategies for guiding when to switch first-line antiretroviral therapy regimens for treatment failure in adults and adolescentsby LW Chang, J Harris, E Humphreys
CD4+ cell count testing more effective than HIV disease clinical staging in identifying pregnant and postpartum women eligible for antiretroviral therapy in resource-limited settingsby Rosalind Carter, Kate Dugan, Wafaa El-Sadr, Landon Myer, Juliana Otieno, Nattaya Pungpapong, Patricia Toro, Elaine Abrams
Effect of point-of-care CD4 cell count tests on retention of patients and rates of antiretroviral therapy initiation in primary health clinics: an observational cohort studyby Ilesh Jani, Nádia Sitoe, Eunice Alfai, Patrina Chongo, Jorge Quevedo, Beatriz Rocha, Jonathan Lehe
Head-to-head comparison of accuracy of a rapid point-of care HIV test with oral versus whole-blood specimensby Nitika Pant Pai, MD MPH PhD, B. Balram, S. Shivkumar, J.L Martinex-Cajas, C. Claessens, G. Lambert, Rosanna Peeling, L. Joseph
This review, written by Ruth McNerney and Peter Daley, provides an overview of the state of research into point-of-care diagnostics for active tuberculosis and highlights the barriers to the development of these tests.