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Aggerbeck et al. determined the optimal dose and specificity of recombinant ESAT-6 and CFP-10 (C-TB) produced in Lactococcus lactis for diagnosis of M. tuberculosis infection. In doing so, the authors discovered that C-Tb offers a simple and convenient skin test to diagnose M.tuberculosis infection. This skin test is also unaffected by the BCG vaccination.
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