Aggerbeck et al. determined the optimal dose and specificity of recombinant ESAT-6 and CFP-10 (C-TB) produced in Lactococcus lactis for diagnosis of M. tuberculosis infection. In doing so, the authors discovered that C-Tb offers a simple and convenient skin test to diagnose M.tuberculosis infection. This skin test is also unaffected by the BCG vaccination.
To read the entire article, published in PLoS ONE, click here.